Jennekens F G, Tomlinson B E, Walton J N
J Neurol Neurosurg Psychiatry. 1972 Feb;35(1):124-32. doi: 10.1136/jnnp.35.1.124.
Samples of the extensor digitorum brevis muscle (EDB) obtained at necropsy from 26 subjects without known neuromuscular disease were examined histologically and histochemically. In the two youngest subjects, aged 2 months and 8 years, a mosaic distribution of type I and type II fibres was present. From the second decade onwards, increasing with age, the mosaic pattern was gradually replaced by groups of type I and type II fibres and areas of grouped fibre atrophy appeared. It is suggested that these findings may be explained by a slow process of denervation and reinnervation. This process does not seem to occur to the same extent in three other distal limb muscles from which specimens were also examined.
对26名无已知神经肌肉疾病的受试者尸检时获取的趾短伸肌（EDB）样本进行了组织学和组织化学检查。在两名最年轻的受试者中，一名2个月大，另一名8岁，可见I型和II型纤维呈镶嵌分布。从第二个十年开始，随着年龄增长，这种镶嵌模式逐渐被I型和II型纤维群取代，出现了成群纤维萎缩区域。有人认为，这些发现可能是由缓慢的去神经和再支配过程所解释。在同样进行了样本检查的其他三块远端肢体肌肉中，这个过程似乎没有以相同程度发生。
