Chesters P M, Heritage J, McCance D J
J Infect Dis. 1983 Apr;147(4):676-84. doi: 10.1093/infdis/147.4.676.
Available evidence suggests that BK virus (BKV) and JC virus (JCV) persist in the kidneys of healthy individuals after primary infection and may reactivate when the host's immune response is impaired. Data supporting this hypothesis are presented. A previous study had shown BKV to be present in the kidneys of eight (57%) of 14 subjects. In the present study, which extended the investigation to a total of 30 subjects, BKV DNA was found in the renal tissues of 10 (33%) subjects, and JCV DNA was found in the renal tissues of three (10%) subjects. The viral DNA detected appeared not to be integrated with host DNA and to be isolated in foci. Investigation of normal and diseased brain tissue, including tissue from six subjects with multiple sclerosis, failed to reveal the presence of either JCV DNA or BKV DNA.
现有证据表明，BK病毒（BKV）和JC病毒（JCV）在初次感染后会持续存在于健康个体的肾脏中，当宿主免疫反应受损时可能会重新激活。文中给出了支持这一假设的数据。先前的一项研究表明，14名受试者中有8名（57%）的肾脏中存在BKV。在本研究中，研究对象扩展至30名受试者，在10名（33%）受试者的肾组织中发现了BKV DNA，在3名（10%）受试者的肾组织中发现了JCV DNA。检测到的病毒DNA似乎未与宿主DNA整合，而是呈灶状分布。对正常和患病脑组织（包括6名多发性硬化症患者的组织）的调查未发现JCV DNA或BKV DNA的存在。
