[2 cases of multicentric glioma].

We reported two cases of multicentric glioma. The first case was 60-year-old female. In CT scan findings, separate mass lesions were observed in the right parieto-occipital area, left parietal lobe and left thalamic region. The second case was 53-year-old male. In CT scan findings, separate mass lesions were observed in the right fronto-parieto-temporal area and left frontal lobe. These two cases were considered to be metastatic brain tumor and radiation therapy and chemoimmunotherapy were performed. But in the postmortem examinations, both cases were evident to be not metastatic brain tumor but glioblastoma multiforme. And tumor cells were not found in commissural or other nerve pathways and cerebrospinal fluid system histologically. So our cases were considered as multicentric glioma. The pathogenesis of multicentric glioma are not understood till now. Therefore, it is interesting that the different histological findings were observed in the each tumor lesion of the first case.