Charlton M P, Thompson C S, Atwood H L, Farnell B
Neurosci Lett. 1980 Feb;16(2):193-6. doi: 10.1016/0304-3940(80)90343-2.
Application of the sodium ionophore, Monensin, to crustacean neuromuscular preparations induced a potentiation of the synaptic potential which subsided after removal of Monensin. The rate and extent of potentiation were influenced by the concentration of extracellular sodium, and potentiation occurred when Monensin was applied in calcium-free solutions. Some features of long-lasting facilitation induced by repetitive stimulation of the motor axon were duplicated by Monensin application. The results support the hypothesis that long-lasting facilitation of transmitter release can result from increased intracellular sodium.
将钠离子载体莫能菌素应用于甲壳类动物神经肌肉制剂时，会引起突触电位增强，去除莫能菌素后该增强作用会消退。增强的速率和程度受细胞外钠浓度的影响，并且当在无钙溶液中应用莫能菌素时会出现增强作用。莫能菌素的应用重现了运动轴突重复刺激所诱导的长时程易化的一些特征。这些结果支持了这样一种假说，即递质释放的长时程易化可能是由细胞内钠增加所致。
