Fadly A M, Witter R L
Avian Dis. 1983 Jan-Mar;27(1):271-82.
Seventy-three percent of chickens inoculated with the chick syncytial strain of reticuloendotheliosis virus (REV) at hatching developed lymphomas by 39 weeks of age. Neonatal treatment with cyclophosphamide or surgical bursectomy at 2, 4, 8, or 12 weeks of age significantly (P less than 0.01) reduced lymphoma development. In a further experiment, surgical bursectomy of REV-infected chickens followed by intravenous inoculation of the chickens with a single cell suspension of their own bursa cells at 2, 4, 9, or 13 weeks of age resulted in lymphoid tumors in chickens treated at 9 or 13 weeks but not in chickens treated at 2 or 4 weeks of age. Furthermore, this treatment did not shorten the incubation period for lymphoma development. These findings argue very strongly that transforming target cells are primarily in the bursa of Fabricius. The data also suggest that a minimum residency of 4 weeks in the bursa is required for infected bursa cells to become transformed. Therefore, lymphomagenesis induced by REV in chickens appears similar to that induced by the avian leukosis virus group.
73%在孵化时接种网状内皮组织增生症病毒（REV）鸡合胞体毒株的鸡，到39周龄时发生了淋巴瘤。在2、4、8或12周龄时用环磷酰胺进行新生儿期治疗或进行手术法氏囊切除，显著（P小于0.01）降低了淋巴瘤的发生。在进一步的实验中，对感染REV的鸡进行手术法氏囊切除，然后在2、4、9或13周龄时给鸡静脉注射其自身法氏囊细胞的单细胞悬液，结果在9或13周龄接受治疗的鸡中出现了淋巴样肿瘤，而在2或4周龄接受治疗的鸡中未出现。此外，这种治疗并没有缩短淋巴瘤发生的潜伏期。这些发现有力地表明，转化靶细胞主要在法氏囊中。数据还表明，感染的法氏囊细胞要发生转化，在法氏囊中至少需要停留4周。因此，REV诱导鸡发生淋巴瘤的过程似乎与禽白血病病毒组诱导的过程相似。
