Li J, Calnek B W, Schat K A, Graham D L
Avian Dis. 1983 Oct-Dec;27(4):1090-105.
A new isolate of reticuloendotheliosis virus (REV) from ducks, RU-1, was used to experimentally infect white pekin ducks. Embryonal or neonatal infection usually resulted in persistent viremias, no REV antibody development, and inability to mount antibody responses against bovine serum albumin (BSA) or sheep red blood cells (SRBC). In contrast, infection at 21 days of age resulted in transient viremias, which terminated coincident with REV antibody development. These ducks remained persistently infected, however, based on virus isolations from peripheral blood lymphocytes. Ducks infected at that age were immunologically competent against BSA and SRBC unless they had been embryonally bursectomized, in which case they behaved virologically and immunologically like those infected at an early age. Bursectomy by itself did not prevent responses against the antigens. Total mortality during 4- or 6-month experimental periods ranged from 80 to 100% in REV-infected groups, regardless of age at infection, route of exposure, or whether the ducks were intact or bursectomized. Most deaths were from non-neoplastic conditions (stunting, bacterial infections), but 17 of 69 (25%) infected ducks developed a variety of neoplasms, including lymphosarcomas, histiocytic sarcomas, and spindle-cell sarcomas.
一种从鸭子中分离出的新型网状内皮组织增生症病毒（REV），即RU-1，被用于实验性感染北京鸭。胚胎期或新生期感染通常会导致持续性病毒血症，不产生REV抗体，并且无法对牛血清白蛋白（BSA）或绵羊红细胞（SRBC）产生抗体反应。相比之下，21日龄时感染会导致短暂性病毒血症，其在REV抗体产生时终止。然而，根据从外周血淋巴细胞中分离出病毒，这些鸭子仍处于持续感染状态。那个年龄段感染的鸭子对BSA和SRBC具有免疫能力，除非它们在胚胎期进行了法氏囊切除，在这种情况下，它们在病毒学和免疫学方面的表现与早期感染的鸭子相似。单独进行法氏囊切除并不能阻止对抗原的反应。在4个月或6个月的实验期内，无论感染时的年龄、暴露途径如何，也无论鸭子是完整的还是进行了法氏囊切除，REV感染组的总死亡率在80%至100%之间。大多数死亡是由非肿瘤性疾病（发育迟缓、细菌感染）引起的，但69只感染鸭子中有17只（25%）发生了各种肿瘤，包括淋巴肉瘤、组织细胞肉瘤和梭形细胞肉瘤。
