Eastwood J B, Stamp T C, Harris E, de Wardener H E
Lancet. 1976 Dec 4;2(7997):1209-11. doi: 10.1016/s0140-6736(76)91140-5.
The plasma level of 25-hydroxy-vitamin D (25-OHD) has been measured and the histological appearances of bone examined in 22 patients with stable chronic renal failure. The results show that osteomalacia occurred only in those patients with relatively low levels of 25-OHD. It is concluded that the osteomalacia of chronic renal failure results from a lack of 25-hydroxy-vitamin D3 superimposed on an existing deficiency of 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D3) rather than from lack of 1,25-(OH)2D3 alone.
对22例稳定期慢性肾衰竭患者测定了血浆25-羟维生素D（25-OHD）水平，并检查了其骨骼的组织学表现。结果显示，骨软化仅发生在那些25-OHD水平相对较低的患者中。得出的结论是，慢性肾衰竭的骨软化是由于叠加在现有的1,25-二羟维生素D3（1,25-(OH)2D3）缺乏之上的25-羟维生素D3缺乏所致，而非仅由于1,25-(OH)2D3缺乏。
