Regional distribution of [3H]imipramine binding sites in the CNS of Roman high and low avoidance rats.

The high affinity binding of [3H]imipramine to membranes was compared in 7 brain regions from two psychogenetically selected rat lines (RHA/Verh, RLA/Verh). A significantly higher binding in RHA/Verh rats, as compared to RLA/Verh rats, was found in cortex and striatum. All other regions, except hypothalamus, showed a trend in the same direction (RHA/Verh greater than RLA/Verh). In the hypothalamus, however, [3H]imipramine binding for RLA/Verh rats significantly exceeded that found in RHA/Verh animals.