Gentsch C, Lichtsteiner M, Feer H
Eur J Pharmacol. 1983 Mar 25;88(2-3):259-61. doi: 10.1016/0014-2999(83)90015-8.
The high affinity binding of [3H]imipramine to membranes was compared in 7 brain regions from two psychogenetically selected rat lines (RHA/Verh, RLA/Verh). A significantly higher binding in RHA/Verh rats, as compared to RLA/Verh rats, was found in cortex and striatum. All other regions, except hypothalamus, showed a trend in the same direction (RHA/Verh greater than RLA/Verh). In the hypothalamus, however, [3H]imipramine binding for RLA/Verh rats significantly exceeded that found in RHA/Verh animals.
在两种经心理遗传学选择的大鼠品系（RHA/Verh、RLA/Verh）的7个脑区中，比较了[3H]丙咪嗪与膜的高亲和力结合情况。与RLA/Verh大鼠相比，在RHA/Verh大鼠的皮质和纹状体中发现结合力显著更高。除下丘脑外，所有其他区域都呈现相同方向的趋势（RHA/Verh大于RLA/Verh）。然而，在下丘脑中，RLA/Verh大鼠的[3H]丙咪嗪结合力显著超过RHA/Verh动物中的结合力。
