Stewart F A, Rojas A, Denekamp J
Int J Radiat Oncol Biol Phys. 1983 Apr;9(4):507-13. doi: 10.1016/0360-3016(83)90069-x.
The radioprotective effect of WR-2721 has been studied in two murine tumors using single doses or five daily fractions. Single dose irradiations of the SA FA resulted in a highly variable radio-protective response. In one experiment large protection factors (1.2-2.5) were obtained, with the greatest protection at low X ray doses. In later experiments with the same tumor, there was little or no radioprotection. The Ca MT was significantly protected against single dose irradiation with both 250 mg/kg and 400 mg/kg of the drug. In a five fraction schedule the extent of radioprotection for CA MT was greater than with single X ray doses for the same drug dose per fraction. Tumor protection factors from the present work and from the literature are compared with published protection factors for normal tissues. Significant tumor radioprotection is seen in most studies. The data indicate more variability in the extent of tumor protection for a given drug dose than is seen in normal tissues. Tumor protection is often greatest at low X ray doses which may be a result of preferential protection of the better-oxygenated tumor cells.
已使用单剂量或每日五次分割剂量研究了WR-2721对两种小鼠肿瘤的辐射防护作用。对SA FA进行单剂量照射产生了高度可变的辐射防护反应。在一项实验中，获得了较大的防护因子（1.2 - 2.5），在低X射线剂量下防护效果最佳。在后来对同一肿瘤进行的实验中，几乎没有或根本没有辐射防护作用。使用250 mg/kg和400 mg/kg的该药物对Ca MT进行单剂量照射时，其受到了显著保护。在五分割方案中，对于Ca MT，辐射防护程度大于相同药物剂量每分割进行单次X射线照射的情况。将本研究及文献中的肿瘤防护因子与已发表的正常组织防护因子进行了比较。在大多数研究中都观察到了显著的肿瘤辐射防护作用。数据表明，对于给定的药物剂量，肿瘤防护程度的变异性比正常组织中更大。肿瘤防护通常在低X射线剂量时最大，这可能是对氧合较好的肿瘤细胞优先保护的结果。
