Keon W J, Akyurekli Y, Taichman G C, Korecky B
Can J Surg. 1978 Mar;21(2):114-8.
In an initial study with dog hearts functioning in situ on total coronary bypass, we demonstrated that predetermined levels of reduced cardiac pump function could be achieved by reducing total coronary flow through changes in the perfusing pressure. In subsequent experiments, oxygen values were measured so that changes in myocardial aerobic consumption in response to brief (3 minute) alterations in coronary perfusing pressure could be determined as well. As a result significant linear correlations were found between coronary flow and myocardial oxygen availability (r = 0.98), oxygen extraction (r = 0.49) and oxygen consumption (r = 0.92). These changes in oxygen values paralleled those in cardiac function (stroke work, r = 0.84).
在一项对原位犬心进行完全冠状动脉搭桥的初步研究中，我们证明，通过改变灌注压力来减少总冠状动脉血流量，可实现预定水平的心脏泵功能降低。在随后的实验中，对氧值进行了测量，以便确定冠状动脉灌注压力短暂（3分钟）改变时心肌有氧消耗的变化情况。结果发现，冠状动脉血流量与心肌氧供应（r = 0.98）、氧摄取（r = 0.49）和氧消耗（r = 0.92）之间存在显著的线性相关性。这些氧值的变化与心脏功能的变化（每搏功，r = 0.84）平行。
