向大鼠脑室急性注射阿片肽：一种巨噬细胞样细胞反应。

Acute injections of opiate peptides into the rat cerebral ventricle: a macrophage-like cellular response.

作者信息

Saland L C, Van Epps D E, Ortiz E, Samora A

出版信息

Brain Res Bull. 1983 Apr;10(4):523-8. doi: 10.1016/0361-9230(83)90150-8.

Abstract

Opiate peptides (beta-endorphin, alpha-endorphin or met-enkephalin) were administered to the lateral cerebral ventricle of adult male rats via single injection into implanted cannulas. Scanning EM of the third ventricle above the median eminence of animals sacrificed approximately one hour after peptide injection revealed numerous free cells above the ependyma. Beta-endorphin induced a significantly greater cellular response than other peptides or control injections. Transmission EM demonstrated that the cells had morphologic characteristics of macrophages. Opiate peptides in cerebrospinal fluid may act as "chemotactic" factors to induce the migration of macrophage-like supraependymal cells.

摘要

通过植入套管单次注射，将阿片肽（β-内啡肽、α-内啡肽或甲硫氨酸脑啡肽）注入成年雄性大鼠的侧脑室。在肽注射后约一小时处死动物，对位于正中隆起上方的第三脑室进行扫描电子显微镜检查，结果显示室管膜上方有大量游离细胞。β-内啡肽诱导的细胞反应比其他肽或对照注射显著更强。透射电子显微镜显示这些细胞具有巨噬细胞的形态学特征。脑脊液中的阿片肽可能作为“趋化”因子，诱导巨噬细胞样室管膜上细胞迁移。