Necas E, Ponka P, Neuwirt J
Cell Tissue Kinet. 1978 Mar;11(2):119-27. doi: 10.1111/j.1365-2184.1978.tb00880.x.
Hydroxyurea injection kills only approximately 10% of CFUs which are in the S phase of the cell cycle. In mice given a single injection of hydroxyurea CFUs in the femur decreased only about 50% in 2--4 days after hydroxyurea, and then started to return to normal levels with an overshoot evident after the eighth day after hydroxyurea. CFUs in spleens of mice given a single injection of hydroxyurea show an evident overshoot as early as 3 days after the drug, reaching levels which are about 300% of normal. CFUs from blood disappear rapidly, but equally rapidly return to normal values followed by a significant overshoot. The radioresistance of mice increased up to 4 days after hydroxyurea.
羟基脲注射液仅杀死约10%处于细胞周期S期的集落形成单位（CFU）。在单次注射羟基脲的小鼠中，股骨中的CFU在注射羟基脲后2 - 4天仅减少约50%，然后开始恢复到正常水平，在羟基脲注射后第8天出现明显的超调现象。单次注射羟基脲的小鼠脾脏中的CFU在用药后3天就出现明显的超调，达到正常水平的约300%。血液中的CFU迅速消失，但同样迅速恢复到正常值，随后出现显著的超调。小鼠的辐射抗性在羟基脲注射后4天内有所增加。
