1型单纯疱疹病毒在耐羟基脲的幼仓鼠肾细胞上的复制
Replication of herpes simplex virus type 1 on hydroxyurea-resistant baby hamster kidney cells.
作者信息
Leary K, Bratton J, Francke B
出版信息
J Virol. 1983 Jul;47(1):224-6. doi: 10.1128/JVI.47.1.224-226.1983.
Abstract
Hydroxyurea-resistant (HUr) baby hamster kidney cells were isolated, subcloned, and characterized. One clonal line, which contained elevated levels of ribonucleotide reductase, lost its HU resistance during passage in the absence of the inhibitor, whereas another clonal line was stably resistant. The replication of herpes simplex virus type 1 on these cells was compared with that of the parvovirus minute virus of mice. Herpes simplex virus type 1 was found to be as sensitive to HU on both lines of HUr baby hamster kidney cells as it was on parental (HU-sensitive) cells, whereas parvovirus replication was about eight times more resistant on HUr baby hamster kidney cells compared with the parental cells. The results suggest that herpes simplex virus type 1 cannot use the cellular reductase and may code for its own.
摘要
分离、亚克隆并鉴定了耐羟基脲（HUr）的幼仓鼠肾细胞。一个克隆系含有高水平的核糖核苷酸还原酶，在无抑制剂传代过程中失去了对羟基脲的抗性，而另一个克隆系则具有稳定抗性。比较了1型单纯疱疹病毒在这些细胞上的复制情况与小鼠细小病毒的复制情况。结果发现，1型单纯疱疹病毒在两株耐羟基脲幼仓鼠肾细胞系上对羟基脲的敏感性与在亲代（对羟基脲敏感）细胞上一样，而细小病毒在耐羟基脲幼仓鼠肾细胞上的复制抗性比在亲代细胞上高约8倍。结果表明，1型单纯疱疹病毒无法利用细胞还原酶，可能编码自身的还原酶。
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