病毒诱导的小鼠糖尿病。

Virus-induced diabetes in mice.

作者信息

Yoon J W, Notkins A L

出版信息

Metabolism. 1983 Jul;32(7 Suppl 1):37-40. doi: 10.1016/s0026-0495(83)80009-2.

Abstract

Encephalomyocarditis (EMC) virus infects and destroys pancreatic beta cells when inoculated into mice. This results in hypoinsulinemia and hyperglycemia. The development of virus-induced diabetes is dependent on the genetic background of the host and the genetic makeup of the virus. In addition to the acute metabolic changes, animals with diabetes for six months show some long-term complications, including reduced life span, glomerulosclerosis, and ocular changes. The development of virus-induced diabetes in mice can be prevented by a live attenuated vaccine.

摘要

脑心肌炎（EMC）病毒接种到小鼠体内时会感染并破坏胰腺β细胞。这会导致低胰岛素血症和高血糖症。病毒诱导的糖尿病的发展取决于宿主的遗传背景和病毒的基因组成。除了急性代谢变化外，患糖尿病六个月的动物还会出现一些长期并发症，包括寿命缩短、肾小球硬化和眼部变化。小鼠中病毒诱导的糖尿病的发展可以通过减毒活疫苗来预防。