Mercola M, Wang X F, Olsen J, Calame K
Science. 1983 Aug 12;221(4611):663-5. doi: 10.1126/science.6306772.
Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (Jh) and the constant region of the mu chain (Cmu) can enhance transcription when it is cloned either 5' or 3' to the SV40 early promoter. The region between C alpha and the alpha switch site, which occurs 5' to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.
对免疫球蛋白重链基因座中的两个区域进行了测试，以检验它们增强SV40早期启动子转录的能力。重链连接区（Jh）与μ链恒定区（Cmu）之间的部分间隔序列，当克隆到SV40早期启动子的5'端或3'端时，均可增强转录。在许多鼠浆细胞瘤中，位于α恒定区（Cα）与α转换位点之间的区域，该区域位于易位的c-myc癌基因的5'端，在该检测中未显示出转录增强子活性。
