Fekete M, Bokor M, Penke B, Telegdy G
Acta Physiol Acad Sci Hung. 1982;60(1-2):57-63.
The effects of peripherally administered cholecystokinin octapeptide sulphate ester and its unsulphated form on the active avoidance behaviour of rats were studied. The acquisition of avoidance behaviour was impaired, while extinction was facilitated, following cholecystokinin octapeptide sulphate ester or unsulphated cholecystokinin octapeptide treatment. These peptides had no action on open-field activity. It is concluded that peripherally administered cholecystokinin octapeptide influences acquisition and extinction of active avoidance behaviour and this effect is unrelated to general motor activity of the animals.
研究了外周给予硫酸化八肽胆囊收缩素及其未硫酸化形式对大鼠主动回避行为的影响。给予硫酸化八肽胆囊收缩素或未硫酸化的八肽胆囊收缩素后，回避行为的习得受到损害，而消退则得到促进。这些肽对旷场活动没有作用。得出的结论是，外周给予八肽胆囊收缩素会影响主动回避行为的习得和消退，且这种作用与动物的一般运动活动无关。
