Cohen S L, Knight M, Tamminga C A, Chase T N
Eur J Pharmacol. 1982 Sep 24;83(3-4):213-22. doi: 10.1016/0014-2999(82)90254-0.
The effect of peripherally administered cholecystokinin-octapeptide (CCK8) was tested on signaled-avoidance behavior, apomorphine-induced stereotypy, and catalepsy. Rats were trained to avoid shock in a signaled shuttle-box avoidance task, and then given CCK8, tetragastrin, or haloperidol. CCK8 (20-3840 micrograms/kg i.p.) reduced avoidance in a dose-dependent manner. The impairment at maximal dose levels was approximately 25% from its predrug level compared to 50% with haloperidol (100 micrograms/kg i.p.). Combined injection of CCK8 (320 micrograms/kg i.p.) and haloperidol (75 micrograms/kg i.p.) reduced avoidance significantly more than either drug alone. The effects of CCK8 were relatively brief in that active avoidance was impaired if CCK8 was injected up to 15 min before the avoidance test. CCK8 also facilitated the extinction of avoidance. Tetragastrin (177 micrograms/kg i.p.), which elicits gastrointestinal effects resembling CCK8, did not affect avoidance. In addition, CCK8 diminished apomorphine-induced stereotypy up to 5 min after CCK8 injection. CCK8 (20-1280 micrograms/kg i.p. and s.c.) failed to produce catalepsy in vertical grip tests. These data suggest that peripherally administered CCK8 has sedative and certain neuroleptic-like effects on behavior.
研究了外周注射八肽胆囊收缩素（CCK8）对信号回避行为、阿扑吗啡诱导的刻板行为和僵住症的影响。在信号穿梭箱回避任务中训练大鼠避免电击，然后给它们注射CCK8、四肽胃泌素或氟哌啶醇。CCK8（腹腔注射20 - 3840微克/千克）以剂量依赖的方式降低回避行为。最大剂量水平时的损害程度比给药前水平降低约25%，而氟哌啶醇（腹腔注射100微克/千克）为50%。联合注射CCK8（腹腔注射320微克/千克）和氟哌啶醇（腹腔注射75微克/千克）比单独使用任何一种药物显著更能降低回避行为。CCK8的作用相对短暂，如果在回避试验前15分钟内注射CCK8，主动回避行为就会受损。CCK8还促进了回避行为的消退。四肽胃泌素（腹腔注射177微克/千克）能引起类似于CCK8的胃肠道效应，但不影响回避行为。此外，CCK8在注射后长达5分钟内可减少阿扑吗啡诱导的刻板行为。在垂直握持试验中，CCK8（腹腔注射和皮下注射20 - 1280微克/千克）未能产生僵住症。这些数据表明，外周注射CCK8对行为具有镇静和某些抗精神病样作用。
