Witherspoon L R, Shuler S E, Garcia M M
Clin Chem. 1978 Mar;24(3):494-8.
Estimates of digoxin in serum with a commercial redioimmunoassay kit (Schwarz/Mann) occasionally result in more counts in the patient's "bound" fraction than in the "bound" fraction for the zero standard. This phenomenon has been investigated in 26 serum samples obtained from patients who were ingesting known amounts of digoxin. The problem appears to relate to environmental differences in at least the zero standard and affects results when serum digoxin concentrations are less than 0.8 microgram/liter. Apparently dose estimates are more accurate with other methods or by calculating results after omitting the zero standard.
使用商用放射免疫分析试剂盒（施瓦茨/曼恩公司）测定血清中地高辛时，偶尔会出现患者“结合”部分的计数高于零标准品“结合”部分计数的情况。对26份来自服用已知剂量地高辛患者的血清样本进行了此项现象的研究。该问题似乎至少与零标准品中的环境差异有关，并且当血清地高辛浓度低于0.8微克/升时会影响结果。显然，使用其他方法或在省略零标准品后计算结果时，剂量估计会更准确。
