Nogaki H, Taomoto K, Tamaki N, Matsumoto S
Gan To Kagaku Ryoho. 1983 Apr;10(4 Pt 1):1007-12.
Nineteen patients with brain tumors were orally administered 300 mg of UFT (a combination of FT and uracil with a molar ratio being 1:4) before operation and the concentrations of FT, 5-FU and Uracil in tumors and serum were measured by chemical assay. Time course of FT in serum rapidly attenuated, but 5-FU was kept almost constant below 0.014 micrograms/ml. T/B ratio (5-FU in tumor/5-FU in blood) in 11 samples of meningioma was 6.86 +/- 3.67, while in 8 samples obtained from glioblastoma was significantly higher (23.79 +/- 11.43, p less than 0.001). In malignant brain tumors there was a correlation between the concentration of 5-FU and Uracil in tumor (gamma = 0.67). This correlation was more enhanced when the value of Uracil in tumor was over 15 micrograms/g (gamma = 0.81). The concentration of 5-FU in cyst was low, but tended to accumulated later. This result may be based on the diffusion of 5-FU from the surrounding solid part of tumor into the cyst. Our present study demonstrated that enhancing effect of 5-FU in brain tumors, particularly solid malignant glioma, was yielded after oral administration of UFT.
19例脑肿瘤患者在手术前口服300毫克优福定（FT与尿嘧啶的摩尔比为1:4的组合），并通过化学分析测定肿瘤和血清中FT、5-氟尿嘧啶（5-FU）和尿嘧啶的浓度。血清中FT的时间进程迅速衰减，但5-FU在0.014微克/毫升以下几乎保持恒定。11例脑膜瘤样本的T/B比值（肿瘤中的5-FU/血液中的5-FU）为6.86±3.67，而8例胶质母细胞瘤样本的该比值显著更高（23.79±11.43，p<0.001）。在恶性脑肿瘤中，肿瘤中5-FU和尿嘧啶的浓度之间存在相关性（γ=0.67）。当肿瘤中尿嘧啶的值超过15微克/克时，这种相关性更强（γ=0.81）。囊肿中5-FU的浓度较低，但后期有积累趋势。这一结果可能是基于5-FU从肿瘤周围的实性部分扩散到囊肿中。我们目前的研究表明，口服优福定后，脑肿瘤尤其是实性恶性胶质瘤中5-FU的增强作用得以产生。
