Hayata Y, Kato H
Gan To Kagaku Ryoho. 1983 Jun;10(6):1387-94.
Two kinds of laser were employed in the treatment of cancers of various organs: a high energy vaporization therapy by a Nd-YAG laser and a photoradiation therapy (PRT) by an argon dye laser (red light with 630 nm wave length) after i.v. administration of hematoporphyrin derivative (HpD). In the former, the lesion was vaporized with a power of 40-80 W with continuous wave or pulse wave transmitted endoscopically. Improved condition was obtained in 59.3% among 27 malignant lesions of the trachea and bronchi. The indications of this method were discussed in relation to the tumor location and type of growth. In PRT the lesion was photoradiated with a power of 100-2,000 mW for 10-30 minutes, 48 hours or more after i.v. injection of 2.5-5.0 mg/kg HpD. PRT was performed in 170 cancer cases consisting of 69 cases of lung cancer, 9 cases of esophageal cancer, 22 cases of gastric cancer, 18 cases of bladder cancer and other 52 cases of various organs. In 29 cases of early stage cancers complete tumor remission was obtained in 65.5%, especially in early stage central type lung cancer. Local effect was obtained in all advanced cases. The method is also available to reduce the extent of resection or to widen the indications of surgery preoperatively. However, there are many problems in PRT such as the activation mechanism of HpD, diagnosis of early stage cancer candidates for PRT, indications and limitations.
一种是通过钕钇铝石榴石激光进行的高能汽化疗法，另一种是在静脉注射血卟啉衍生物（HpD）后，通过氩染料激光（波长630nm的红光）进行的光辐射疗法（PRT）。在前者中，通过内镜传输连续波或脉冲波，以40-80W的功率汽化病变。在27例气管和支气管恶性病变中，59.3%的病情得到改善。结合肿瘤位置和生长类型讨论了该方法的适应症。在PRT中，在静脉注射2.5-5.0mg/kg HpD后48小时或更长时间，以100-2000mW的功率对病变进行10-30分钟的光辐射。PRT应用于170例癌症患者，包括69例肺癌、9例食管癌、22例胃癌、18例膀胱癌以及其他52例来自各种器官的癌症患者。在29例早期癌症中，65.5%实现了肿瘤完全缓解，尤其是早期中央型肺癌。所有晚期病例均获得局部疗效。该方法也可用于减少切除范围或在术前扩大手术适应症。然而，PRT存在许多问题，如HpD的激活机制、PRT候选早期癌症的诊断、适应症和局限性。
