Sokolova I N
Arkh Patol. 1983;45(4):30-6.
Clinical and morphological examinations were carried out in 159 children with nephroblastoma. A working histological classification of tumors with reference to prognosis is proposed. It includes typical (89 cases) and atypical (23 cases) variants of the tumor. Among typical tumors, those with predominance of nondifferentiated blastema are distinguished. The atypical tumors include tubular fetal rhabdomyomatous, cystic, sarcomatous (rhabdoid, clear cell) variants. A group of tumors with marked therapeutic pathomorphosis (27 cases) is distinguished among unclassified tumors. Unfavourable prognosis in tumors with predominance of undifferentiated blastema, sarcomatous variants, and tumors with marked therapeutic pathomorphosis is indicated. Attention is drawn to increased number of glomerulo-like structures and cell anaplasia as a possible unfavourable prognostic sign.
对159例肾母细胞瘤患儿进行了临床和形态学检查。提出了一种参照预后的肿瘤工作组织学分类方法。它包括肿瘤的典型（89例）和非典型（23例）变体。在典型肿瘤中，区分出以未分化胚基为主的肿瘤。非典型肿瘤包括管状胎儿横纹肌瘤样、囊性、肉瘤样（横纹肌样、透明细胞）变体。在未分类的肿瘤中区分出一组具有明显治疗病理形态改变的肿瘤（27例）。指出以未分化胚基为主的肿瘤、肉瘤样变体以及具有明显治疗病理形态改变的肿瘤预后不良。注意到肾小球样结构数量增加和细胞间变作为可能的不良预后征象。
