Schmidt D, Harms D
Klin Padiatr. 1983 May-Jun;195(3):214-21. doi: 10.1055/s-2008-1034071.
101 cases of Wilms' tumor (nephroblastoma) were investigated by light microscopy. In 80 cases a diagnosis of triphasic nephroblastoma was made. 21 cases were classified as special variants of Wilms' tumor. These included congenital mesoblastic nephroma (n = 5), fetal rhabdomyomatous nephroblastoma (n = 2), cystic partially differentiated nephroblastoma (n = 3), nephroblastoma with focal or diffuse anaplasia (n = 2), clear cell sarcoma or bone metastasizing renal tumor of childhood (n = 4), rhabdoid tumor (n = 2) and rhabdomyosarcomatous nephroblastoma (n = 3). Based on our own follow-up data and on information from the literature we propose to separate the group of nephroblastomas into three categories of different prognosis: 1. Nephroblastomas of low risk (congenital mesoblastic nephroma, fetal rhabdomyomatous nephroblastoma, cystic partially differentiated nephroblastoma) - in most of these cases simple nephrectomy sufficient as adequate therapy. 2. Nephroblastomas of standard risk (triphasic nephroblastomas) - therapy according to stage of disease. 3. Nephroblastomas of high risk (nephroblastomas with focal or diffuse anaplasia, clear cell sarcoma, rhabdoid tumor, rhabdomyosarcomatous nephroblastoma) - successful therapy has as yet to be developed.
通过光学显微镜对101例肾母细胞瘤进行了研究。其中80例诊断为三相性肾母细胞瘤。21例被归类为肾母细胞瘤的特殊变体。这些包括先天性中胚层肾瘤（n = 5）、胎儿横纹肌样肾母细胞瘤（n = 2）、囊性部分分化肾母细胞瘤（n = 3）、伴有局灶性或弥漫性间变的肾母细胞瘤（n = 2）、透明细胞肉瘤或儿童骨转移性肾肿瘤（n = 4）、横纹肌样瘤（n = 2）和横纹肌肉瘤样肾母细胞瘤（n = 3）。基于我们自己的随访数据以及文献中的信息，我们建议将肾母细胞瘤分为三类预后不同的类型：1. 低风险肾母细胞瘤（先天性中胚层肾瘤、胎儿横纹肌样肾母细胞瘤、囊性部分分化肾母细胞瘤）——在大多数这些病例中，单纯肾切除术足以作为充分的治疗方法。2. 标准风险肾母细胞瘤（三相性肾母细胞瘤）——根据疾病分期进行治疗。3. 高风险肾母细胞瘤（伴有局灶性或弥漫性间变的肾母细胞瘤、透明细胞肉瘤、横纹肌样瘤、横纹肌肉瘤样肾母细胞瘤）——尚未开发出成功的治疗方法。
