Cook M E, Springer W T
Avian Dis. 1983 Apr-Jun;27(2):367-77.
The immunocompetence of 8-week-old reovirus WVU 2937-infected and uninfected chickens fed various dietary levels of biotin, niacin, choline, or folic acid was evaluated in four experiments. Antibody production to sheep red blood cells (SRBC), wattle responses to phytohemagglutinin-P (PHA-P), and wattle responses of tuberculin-sensitized chickens to bovine-purified protein derivative (PPD) were examined in five chickens per treatment. Dietary deficiencies had no effect on the in vivo T-cell immune responses to PPD, PHA-P, or humoral hemagglutinating-antibody production to SRBC. Reovirus-infected and uninfected chickens fed biotin at double the National Research Council (1977) requirement demonstrated decreased PPD responses. Lower hemagglutinating-antibody titers in the uninfected chickens and increased titers in the infected chickens were observed in those fed 200% of the requirement of biotin when compared with the chickens fed 20% and 100% biotin diets. Reovirus infection had no effect on PPD and PHA-P responses. However, in the choline experiment, reovirus-infected chickens had elevated titers. These data indicate that reovirus infection had no adverse effect on the immunocompetence of chickens 8 weeks postinfection. Dietary deficiencies also had no adverse effect on the immunocompetence of 8-week-old reovirus-infected and uninfected chickens.
在四项实验中，对8周龄感染呼肠孤病毒WVU 2937和未感染的鸡饲喂不同日粮水平的生物素、烟酸、胆碱或叶酸后的免疫能力进行了评估。在每个处理组中选取5只鸡，检测其对绵羊红细胞（SRBC）的抗体产生、对植物血凝素-P（PHA-P）的肉垂反应，以及结核菌素致敏鸡对牛纯化蛋白衍生物（PPD）的肉垂反应。日粮缺乏对鸡体内对PPD、PHA-P的T细胞免疫反应或对SRBC的体液血凝抗体产生没有影响。感染呼肠孤病毒和未感染的鸡，饲喂两倍于美国国家研究委员会（1977年）需求量的生物素后，其对PPD的反应降低。与饲喂20%和100%生物素日粮的鸡相比，饲喂200%生物素需求量的未感染鸡的血凝抗体滴度较低，而感染鸡的血凝抗体滴度则升高。呼肠孤病毒感染对PPD和PHA-P反应没有影响。然而，在胆碱实验中，感染呼肠孤病毒的鸡的滴度升高。这些数据表明，呼肠孤病毒感染对感染后8周龄鸡的免疫能力没有不利影响。日粮缺乏对8周龄感染呼肠孤病毒和未感染的鸡的免疫能力也没有不利影响。
