McClure J, Smith P S, Gramp A A
J Clin Pathol. 1983 Aug;36(8):894-902. doi: 10.1136/jcp.36.8.894.
The post-mortem examination of an unsuspected case of alkaptonuria revealed extensive ochronosis. Histological examination of undecalcified sections of tracheal, costal, femoral and patellar cartilage revealed, in addition to ochronotic pigment, extensive calcium pyrophosphate dihydrate (CPPD) deposition. Similar deposits were present in intervertebral discs and were related to ossification of the discs resulting in partial or complete ankylosis. The calcific deposits were present around chondrocytes in the articular cartilage and this may be an important factor in the initiation of the osteoarthrotic process which characterises ochronotic arthropathy as it affects large diarthrodial joints.
对一例未被怀疑的尿黑酸尿症病例进行的尸检显示有广泛的褐黄病。对气管、肋骨、股骨和髌骨软骨的未脱钙切片进行组织学检查发现，除了褐黄病色素外，还有广泛的二水焦磷酸钙（CPPD）沉积。椎间盘也有类似的沉积物，并且与椎间盘骨化有关，导致部分或完全强直。钙化沉积物存在于关节软骨的软骨细胞周围，这可能是骨关节炎过程起始的一个重要因素，骨关节炎过程是褐黄病性关节病影响大的滑膜关节时的特征表现。
