豚鼠主肺动脉兴奋性神经肌肉传递的电生理研究。
An electrophysiological study of excitatory neuromuscular transmission in the guinea-pig main pulmonary artery.
作者信息
Suzuki H
出版信息
J Physiol. 1983 Mar;336:47-59. doi: 10.1113/jphysiol.1983.sp014565.
Abstract
Electrical responses of single smooth muscle cells to perivascular nerve stimulation were recorded in the guinea-pig main pulmonary artery with a micro-electrode, to investigate neuromuscular transmission mechanisms. Perivascular nerve stimulation produced excitatory junction potentials in the smooth muscle cells of the main pulmonary artery. When stimulation was repetitive and of high frequency, a spike was seen in the early part of these potentials. Phentolamine, prazosin, phenoxybenzamine, guanethidine or tetrodotoxin all suppressed first the spike and then the junction potential. Exogenously applied noradrenaline also produced depolarization, and in high concentrations above 10(-6) M, spikes. Phentolamine again suppressed the spikes and then the depolarization. The results suggest that endogenous and exogenous noradrenaline act on the same type of receptor in this artery.
摘要
为研究神经肌肉传递机制，用微电极记录豚鼠主肺动脉中单个平滑肌细胞对血管周围神经刺激的电反应。血管周围神经刺激在主肺动脉平滑肌细胞中产生兴奋性接头电位。当刺激重复且频率较高时，在这些电位的早期出现一个峰电位。酚妥拉明、哌唑嗪、酚苄明、胍乙啶或河豚毒素均先抑制峰电位，然后抑制接头电位。外源性应用去甲肾上腺素也产生去极化，且在高于10(-6)M的高浓度时产生峰电位。酚妥拉明再次先抑制峰电位，然后抑制去极化。结果提示内源性和外源性去甲肾上腺素在该动脉中作用于同一类型受体。
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