Schauf C L
J Physiol. 1983 Apr;337:173-82. doi: 10.1113/jphysiol.1983.sp014618.
Substitution of heavy water (D2O) for H2O slows the Na+ and K+ currents in Myxicola giant axons by 40-50% at 5 degrees C. In contrast, the delays in Na+ K+ activation which can be produced by hyperpolarizing pre-pulses are not affected by solvent substitution. We suggest that in the cascade of transitions leading to the opening of Na+ and K+ channels, D2O affects only the final step that establishes the aqueous pore across the membrane.
在5摄氏度时，用重水（D2O）替代H2O可使黏液虫巨型轴突中的Na+和K+电流减慢40%-50%。相比之下，超极化预脉冲所产生的Na+、K+激活延迟不受溶剂替代的影响。我们认为，在导致Na+和K+通道开放的一系列转变中，D2O仅影响形成跨膜水相孔道的最后一步。
