MacLeod A R, Talbot K
J Mol Biol. 1983 Jul 5;167(3):523-37. doi: 10.1016/s0022-2836(83)80096-5.
We have isolated and characterized a human genomic DNA sequence that defines a family of closely related sequences. At least one member of this family expresses a 2.5 X 10(3) base messenger RNA transcript encoding a 30,000 molecular weight tropomyosin in human fibroblasts. The coding sequence of this mRNA but not the non-coding sequence is also related to that of a 1.1 X 10(3) base mRNA encoding a 36,000 molecular weight non-muscle tropomyosin. This demonstrates the existence of at least two functional genes encoding human non-muscle tropomyosins.
我们已经分离并鉴定了一段人类基因组DNA序列，该序列定义了一个紧密相关的序列家族。这个家族中至少有一个成员在人类成纤维细胞中表达一种2.5×10³个碱基的信使RNA转录本，其编码一种分子量为30,000的原肌球蛋白。该mRNA的编码序列而非非编码序列也与一种编码分子量为36,000的非肌肉原肌球蛋白的1.1×10³个碱基的mRNA的编码序列相关。这证明了至少存在两个编码人类非肌肉原肌球蛋白的功能基因。
