人垂体肿瘤中高比例S期细胞的意义

Significance of high percentages of S-phase cells in human pituitary tumours.

作者信息

Anniko M, Tribukait B, Wersäll J

出版信息

ORL J Otorhinolaryngol Relat Spec. 1983;45(4):177-86. doi: 10.1159/000275641.

Abstract

Using the flow-cytofluorometric technique, 47 consecutive cases of pituitary tumours were analyzed regarding DNA ploidy and the percentage of cells in different phases of the cell cycle. About 20,000-30,000 cells from each tumour were analyzed. Tumours causing acromegaly showed a higher incidence of high percentages of S-phase cells (greater than or equal to 10%) than any other endocrinological type of pituitary tumour. 3 of 6 tumours with high percentages of S-phase cells showed clinically aggressive growth patterns.

摘要

采用流式细胞荧光测定技术，对47例连续性垂体肿瘤病例的DNA倍性及细胞周期不同阶段的细胞百分比进行了分析。对每个肿瘤约20,000 - 30,000个细胞进行了分析。导致肢端肥大症的肿瘤相比其他任何内分泌类型的垂体肿瘤，S期细胞百分比高（大于或等于10%）的发生率更高。6例S期细胞百分比高的肿瘤中有3例表现出临床侵袭性生长模式。