Mann J F, Hausen M, Kutter A, Sudhoff R, Ritz E
Proc Eur Dial Transplant Assoc. 1983;19:788-9.
Beta-receptor responsiveness was evaluated in 24-hour nephrectomised rats. Heart rate responses following intravenous isoproterenol injections into conscious uraemic (n = 9) and sham operated controls (n = 7) were measured. These preliminary results indicate that heart rate at rest and after blockade of the autonomic nervous system was slower in uraemic rats. Blood pressure before and after autonomic blockade was not different between groups, Maximal heart rate increase following intravenous isoproterenol was significantly less pronounced in uraemic than 0.05). The blood pressure decreasing effect of intravenous isoproterenol was enhanced in the nephrectomised group (p less than 0.01).
在切除肾脏24小时的大鼠中评估β受体反应性。对清醒的尿毒症大鼠（n = 9）和假手术对照组（n = 7）静脉注射异丙肾上腺素后测量心率反应。这些初步结果表明，尿毒症大鼠静息时以及自主神经系统被阻断后的心率较慢。两组间自主神经阻断前后的血压无差异，尿毒症大鼠静脉注射异丙肾上腺素后最大心率增加明显不如对照组（p < 0.05）。肾切除组中静脉注射异丙肾上腺素的降压作用增强（p < 0.01）。
