Cirić O, Susić D
Endokrinologie. 1980 Dec;76(3):274-8.
The effects of a beta-adrenergic agonist, 1-isoproterenol, on heart rate and systemic blood pressure were examined in female rats in different phases of the oestrous cycle. In addition, the effect of isoproterenol on the same variables was studied in ovariectomized rats and ovariectomized rats treated with either oestradiol or progesterone. To this end, heart rate and blood pressure were monitored for 10 min after i.v. injection of isoproterenol (80 micrograms/kg). After isoproterenol injection, the heart rate was found to be significantly (p less than 0.05) higher in rats in the prooestrous phase of the cycle than in rats in the metaoestrous phase. Furthermore, isoproterenol induced a significantly (p less than 0.05) greater increase in heart rate in ovariectomized rats treated with oestradiol, than in ovariectomized otherwise nontreated animals or ovariectomized rats treated with progesterone. No difference in blood pressure response to isoproterenol was observed between the groups. The results indicate that oestrogens modify cardiovascular response to a beta-adrenergic stimulator, possibly by affecting beta-adrenergic receptors in the heart.
在雌性大鼠动情周期的不同阶段，研究了β-肾上腺素能激动剂1-异丙肾上腺素对心率和全身血压的影响。此外，还研究了异丙肾上腺素对去卵巢大鼠以及用雌二醇或孕酮处理的去卵巢大鼠相同变量的影响。为此，静脉注射异丙肾上腺素（80微克/千克）后，监测心率和血压10分钟。注射异丙肾上腺素后，发现处于动情前期的大鼠心率显著高于动情后期的大鼠（p<0.05）。此外，与未处理的去卵巢动物或用孕酮处理的去卵巢大鼠相比，用雌二醇处理的去卵巢大鼠中，异丙肾上腺素引起的心率增加显著更大（p<0.05）。各实验组之间未观察到对异丙肾上腺素的血压反应差异。结果表明，雌激素可能通过影响心脏中的β-肾上腺素能受体来改变心血管系统对β-肾上腺素能刺激物的反应。
