Lemenager J, Benard Y, Langeard M
Sem Hop. 1983 Jun 2;59(22):1665-7.
Fifty patients were diagnosed bronchopulmonary Haemophilus infections, because of the production of a purulent sputum, containing at least 10(8) Haemophilus influenzae per ml. Among them were 36 males (average 52 years old) and 14 females (average 58 years old). There was a high percentage (64%) of smokers (over 30 packs/year) within this population, which also included heavy drinkers. The top incidence occurred in winter and spring. Most cases were related to an acute infection in a chronic bronchitis (26 cases). The other cases included 6 cancers, 6 sequelae of tuberculosis, 4 bronchiectasis, 4 asthma, and only 3 pulmonary consolidations. There usually was a low grade fever (only 8 cases reached or went beyond 38 degrees, while in 29 cases the body temperature kept below 38 degrees). The return to a normal temperature was obtained after 4 to 10 days of ampicillin therapy, with no fatal case within this series. The 50 strains were studied by the microbiology laboratory. The minimum inhibitory concentrations showed an elective response to ampicillin and erythromycin, and a less dramatic response to chloramphenicol and tetracyclin. Some strains were proved resistant (MIC over 4 micrograms per ml) to cefoxitin and cefamandole.
50名患者被诊断为支气管肺部嗜血杆菌感染，原因是咳出脓性痰液，每毫升痰液中至少含有10⁸ 流感嗜血杆菌。其中男性36名（平均年龄52岁），女性14名（平均年龄58岁）。该人群中吸烟者（每年超过30包）比例很高（64%），其中还包括酗酒者。发病高峰期出现在冬春季节。大多数病例与慢性支气管炎急性感染有关（26例）。其他病例包括6例癌症、6例肺结核后遗症、4例支气管扩张、4例哮喘，仅有3例肺部实变。通常有低热（仅8例体温达到或超过38度，29例体温持续低于38度）。氨苄西林治疗4至10天后体温恢复正常，该组无死亡病例。微生物实验室对50株菌株进行了研究。最低抑菌浓度显示对氨苄西林和红霉素有选择性反应，对氯霉素和四环素的反应则不那么显著。一些菌株被证明对头孢西丁和头孢孟多耐药（最低抑菌浓度超过每毫升4微克）。
