Feldman C, Smith C, Kaka S, De Jong P, Promnitz D A
Department of Medicine, Hillbrow Hospital, Johannesburg.
S Afr Med J. 1992 May 16;81(10):495-8.
Fifty-seven patients, from whose sputum Haemophilus influenzae (49 cases) or Haemophilus parainfluenzae (8 cases) was isolated during a 7-month period, were studied. In the majority of cases there were well-defined predisposing factors to respiratory tract colonisation or infection with the isolates, in particular bronchiectasis and chronic obstructive airways disease. Colonisation of the airways, bronchopneumonia in patients with underlying lung disease, acute lobar pneumonia, and postoperative chest infections were the commonest clinical diagnoses. Primary acute lobar pneumonia with these organisms alone was uncommon. All of the H. influenzae isolates were nontypeable, and there was a wide range of biotypes of both organisms. Three H. influenzae isolates produced beta-lactamase, and there was, in general, a low incidence of resistance to a wide range of antimicrobial agents on disc susceptibility testing.
在7个月的时间里，对57例痰液中分离出流感嗜血杆菌（49例）或副流感嗜血杆菌（8例）的患者进行了研究。在大多数病例中，存在明确的呼吸道定植或感染这些分离菌的易感因素，特别是支气管扩张和慢性阻塞性气道疾病。气道定植、基础肺部疾病患者的支气管肺炎、急性大叶性肺炎和术后胸部感染是最常见的临床诊断。仅由这些病原体引起的原发性急性大叶性肺炎并不常见。所有流感嗜血杆菌分离株均为不可分型，两种病原体均有广泛的生物型。3株流感嗜血杆菌分离株产生β-内酰胺酶，总体而言，在纸片药敏试验中对多种抗菌药物的耐药率较低。
