Ekoe J M, Albert J
Sem Hop. 1983 Jun 2;59(22):1705-7.
Various immunological mechanisms help to understand the epidemiological and biological heterogenicity of type 1 Diabetes Mellitus. Immunological mechanisms are involved in the destruction of beta cells and perhaps explain the prevalence of Diabetes Mellitus among certain patients with well defined genetic markers. Certain cases of Diabetes Mellitus seem to be mediated by auto-immune processes (cellular or humoral) and thus have a common denominator with other endocrinological diseases. Other immunological mechanisms are incriminated in the development of insulin resistance during exogenous insulin treatment of type 1 Diabetes Mellitus. Resistance to endogenous insulin which characterises type 2 Diabetes Mellitus is related to a decrease in number and density of peripheral insulin receptors.
多种免疫机制有助于理解1型糖尿病的流行病学和生物学异质性。免疫机制参与β细胞的破坏，或许可以解释在某些具有明确遗传标记的患者中糖尿病的患病率。某些糖尿病病例似乎是由自身免疫过程（细胞或体液）介导的，因此与其他内分泌疾病有共同特征。其他免疫机制与1型糖尿病外源性胰岛素治疗期间胰岛素抵抗的发生有关。2型糖尿病所特有的对内源性胰岛素的抵抗与外周胰岛素受体数量和密度的降低有关。
