脑肿瘤对灰质葡萄糖利用抑制的正电子发射断层扫描研究
Positron emission tomographic study of suppression of gray-matter glucose utilization by brain tumors.
作者信息
DeLaPaz R L, Patronas N J, Brooks R A, Smith B H, Kornblith P L, Milam H, Di Chiro G
出版信息
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):826-9.
Positron emission tomography (PET) scanning with [18F]-2-fluoro-2-deoxy-D-glucose (FDG) was used to study 59 patients with astrocytomas and three patients with other cerebral mass lesions. Suppression of gray-matter glucose utilization ranging from 8% to 64% (mean, 30%) was seen in 92% of cases. Three categories of suppression were apparent, with the greatest degrees of suppression occurring in edematous gray matter adjacent to mass lesions. Lesser degrees of suppression were noted in nonedematous structures (normal attenuation on computed tomographic scan) adjacent to the lesion. Significant suppression was also present in gray matter spatially remote from but functionally linked to the site of the lesion. This approach may become a useful tool for improved understanding of the clinical presentation of certain pathologic entities and for evaluation of disease progression and response to treatment.
采用正电子发射断层扫描（PET）技术，以[18F]-2-氟-2-脱氧-D-葡萄糖（FDG）对59例星形细胞瘤患者和3例其他脑部肿块病变患者进行研究。92%的病例中可见灰质葡萄糖利用率抑制范围为8%至64%（平均30%）。抑制分为三类，抑制程度最大的发生在肿块病变附近的水肿灰质中。在病变附近的非水肿结构（计算机断层扫描正常衰减）中观察到较轻程度的抑制。在空间上远离病变但功能上与之相关的灰质中也存在明显抑制。这种方法可能成为一种有用的工具，有助于更好地理解某些病理实体的临床表现，并评估疾病进展和对治疗的反应。
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