Voropaeva S D, Emel'ianova A I, Ankirskaia A S, Saakian S S, Maĭorova V N
Antibiotiki. 1983 Jun;28(6):456-61.
The use of cephotaxim in the treatment of obstetric and gynecological patients with various infectious complications, as well as in the treatment of newborn infants in the Department of Intensive Therapy showed it to be highly effective in 100 per cent of the cases. The adverse reactions of cephotaxim were observed in 1 out of 43 patients. It should be noted that cephotaxim did not inhibit the host anaerobic indigenous flora. No cases of dysbacteriosis were recorded. Comparative analysis of the data on determination of the MIC of cephotaxim and cephuroxim with respect to various species of opportunistic microorganisms demonstrated that cephuroxim was more active against Staph. aureus, while cephotaxim against Klebsiella. Cephotaxim displayed activity against part of the strains of Ps. aeruginosa and streptococci of group D, which was not common to cephalosporins of the previous generations.
头孢噻肟用于治疗患有各种感染性并发症的妇产科患者以及重症治疗科的新生儿，结果显示在所有病例中该药的有效率达100%。43例患者中有1例出现了头孢噻肟的不良反应。应当指出，头孢噻肟并不抑制宿主体内的厌氧固有菌群。未记录到菌群失调的病例。对头孢噻肟和头孢呋辛针对各种机会性微生物的最低抑菌浓度（MIC）测定数据进行的比较分析表明，头孢呋辛对金黄色葡萄球菌的活性更强，而头孢噻肟对克雷伯菌的活性更强。头孢噻肟对部分铜绿假单胞菌菌株和D组链球菌具有活性，这是前代头孢菌素所不具备的特性。
