Konno T, Tashiro S, Maeda H, Iwai K, Ogata K, Mochinaga M, Uemura K, Ishimaru S, Miyauchi Y, Yokoyama I
Gan To Kagaku Ryoho. 1983 Feb;10(2 Pt 2):351-7.
A lymphographic agent, Ethiodol, injected via the hepatic artery was found to remain selectively in the tumor vessels of hepatoma for a long time in our clinic. Taking advantage of this selective continuous peripheral embolization, a lipophilic high molecular anticancer agent, SMANCS (Copolymer of styrene maleic acid conjugated to Neocarzinostatin) dissolved in Ethiodol was administered via the celiac axis or the hepatic artery with Seldinger's method. Anticancer effect was examined by histological findings of specimens removed using hepatic resection (13 cases) and autopsy (1 case) in 14 patients receiving this treatment. Anticancer effect of this treatment became clear through histological findings. In the patients administered SMANCS more than 0.26 mg per 1 cm2 of maximum cut-surface area, complete or widespread necrosis of the tumor occurred, whereas non-cancerous liver tissue remained unaffected.
在我们的临床研究中发现，经肝动脉注射的淋巴造影剂乙碘油能长时间选择性地滞留于肝癌的肿瘤血管中。利用这种选择性持续外周栓塞，采用Seldinger法经腹腔动脉或肝动脉给予溶解于乙碘油中的亲脂性高分子抗癌剂丝裂霉素（苯乙烯马来酸与新制癌菌素的共聚物）。通过对接受该治疗的14例患者经肝切除（13例）及尸检（1例）获取的标本进行组织学检查来评估抗癌效果。通过组织学检查明确了该治疗的抗癌效果。在最大切面面积每1平方厘米给予丝裂霉素超过0.26毫克的患者中，肿瘤出现完全或广泛坏死，而非癌肝组织未受影响。
