Maeda H
Dept. of Microbiology, Kumamoto University, Medical School.
Gan To Kagaku Ryoho. 1989 Oct;16(10):3323-31.
Lipiodol, an oily contrast medium, is utilized to deliver the anticancer agent SMANCS to the target tumor in which the tumor selective delivery of 2,500 fold more than plasma was confirmed with prolonged retention in the tumor tissue. This unique tumor targeting is accomplished by the arterial injection of the oily formulation of the drug. The method utilizes unique vascular properties of tumor tissue. SMANCS is a derivative of neocarzinostatin conjugated with copolymer of styrene and maleic acid. It has much propronounced lipophilicity, stability against various harsh environments and exerts a potent cytotoxicity. Therapeutic effect of the drug to unresectable primary hepatoma is much better than the conventional method. For Child A category patients with intrahepatic metastasis in no more than three area, a 3 yr survival rate is more than 87%. When the Child's A and B are combined with no distant metastasis, 1-, 2- and 3-year survival rates are 87%, 50%, and 35%, respectively. The side effect of this treatment [SMANCS/Lipiodol, i.p.] is minimal; transitory low grade fever is the commonest one (40-50% of cases) which can be controlled by a routine protocol. No liver or marrow toxicity was observed. Procedural limitations for the lung cancer etc. are discussed.
碘油，一种油性造影剂，被用于将抗癌药物丝裂霉素（SMANCS）输送到靶肿瘤，在该肿瘤中已证实其肿瘤选择性递送比血浆高2500倍，且在肿瘤组织中保留时间延长。这种独特的肿瘤靶向作用是通过动脉注射该药物的油性制剂来实现的。该方法利用了肿瘤组织独特的血管特性。SMANCS是与苯乙烯和马来酸共聚物结合的新制癌菌素衍生物。它具有更强的亲脂性、对各种恶劣环境的稳定性，并具有强大的细胞毒性。该药物对不可切除的原发性肝癌的治疗效果比传统方法要好得多。对于Child A类且肝内转移不超过三个区域的患者，3年生存率超过87%。当Child A和B类患者合并且无远处转移时，1年、2年和3年生存率分别为87%、50%和35%。这种治疗方法（SMANCS/碘油，腹腔注射）的副作用极小；短暂的低热是最常见的副作用（40 - 50%的病例），可通过常规方案控制。未观察到肝脏或骨髓毒性。文中还讨论了肺癌等疾病的操作局限性。
