Acebutolol (400 mg) given as a single daily dose to hypertensive patients previously stabilized on 400 mg acebutolol daily in divided doses: an open multicentre study.

An open multicentre trial was carried out in 13 hypertensive patients, who had responded satisfactorily to and been stabilized on treatment with 400 mg acebutolol daily in divided doses, to assess the effectiveness and tolerance of the same daily dosage given as a single morning dose. On admission, patients were changed over immediately to the new dosage regimen and continued on it for 3 months. Blood pressure and pulse rate measurements were made on the day before change over and then at the end of each month. The results indicated that once-a-day 400 mg acebutolol gave satisfactory continued control of blood pressure. Side-effects reported spontaneously by the patient, observed by the physician, and elicited in response to a questionnaire, diminished in incidence and severity in most of the patients during the trial period.