Low L P, Koh T H
Ann Acad Med Singap. 1981 Oct;10(4 Suppl):11-4.
Acebutolol is a relatively "cardioselective" beta-adrenergic blocking agent with an antihypertensive action. The aims of this investigation were to establish the effective dosage range, to study the effect on supine, standing and exercise blood pressure (BP) and heart rate (HR), and to compare the efficacy of once daily (OM) with twice daily (BD) dosing of acebutolol. This was a within patient, double-blind, randomised study. This study shows that the optimum dosage of acebutolol for control of BP and heart rate is 400mg or more daily, and that OM dosing seems to be as effective as BD dosing for supine, standing and post exercise BP control, but is less so for heart rate control.
醋丁洛尔是一种具有降压作用的相对“心脏选择性”β-肾上腺素能阻滞剂。本研究的目的是确定有效剂量范围，研究其对仰卧位、站立位及运动时血压（BP）和心率（HR）的影响，并比较醋丁洛尔每日一次（OM）与每日两次（BD）给药的疗效。这是一项患者自身对照、双盲、随机研究。本研究表明，醋丁洛尔控制血压和心率的最佳剂量为每日400mg或更高，并且每日一次给药在控制仰卧位、站立位及运动后血压方面似乎与每日两次给药同样有效，但在控制心率方面效果较差。
