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不同来源的巨调节蛋白对哺乳动物和酵母磷酸蛋白磷酸酶的刺激作用。

Stimulation of mammalian and yeast phosphoprotein phosphatases by megamodulins from various sources.

作者信息

Kuo W N

出版信息

Biochem Biophys Res Commun. 1983 Jul 18;114(1):403-9. doi: 10.1016/0006-291x(83)91641-8.

DOI:10.1016/0006-291x(83)91641-8
PMID:6309172
Abstract

Phosphoprotein phosphatases (PPase) were isolated from either the rabbit cerebral cortex or Baker's yeast by excluding endogenous megamodulin with histone, and then by desalting cations with Bio-Gel P-6DG filtration. The stimulation of PPase in the presence of Mn2+ was greatly enhanced by megamodulins prepared from various sources including rabbit brain, Baker's yeast, wheat germ, and Escherichia coli (E. coli). Moreover, the augmented activity of PPase was also demonstrated in the presence of [megamodulin-Mn2+] complex.

摘要

通过用组蛋白排除内源性巨调节蛋白，然后用Bio-Gel P-6DG过滤去除阳离子，从兔大脑皮层或面包酵母中分离出磷蛋白磷酸酶（PPase）。在存在Mn2+的情况下，PPase的活性受到来自各种来源（包括兔脑、面包酵母、小麦胚芽和大肠杆菌）制备的巨调节蛋白的极大增强。此外，在存在[巨调节蛋白-Mn2+]复合物的情况下，PPase的活性也得到了增强。

相似文献

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Stimulation of mammalian and yeast phosphoprotein phosphatases by megamodulins from various sources.不同来源的巨调节蛋白对哺乳动物和酵母磷酸蛋白磷酸酶的刺激作用。
Biochem Biophys Res Commun. 1983 Jul 18;114(1):403-9. doi: 10.1016/0006-291x(83)91641-8.
2
Multiforms of megamodulin-dependent protein kinases from baker's yeast.来自面包酵母的巨调节蛋白依赖性蛋白激酶的多种形式。
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Interaction of brain megamodulin with nicotinamide adenine dinucleotide, phosphohistones and adenosine triphosphate.
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Partial purification and characterization of the cation-binding protein and megamodulin from E. coli.
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Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1.蛋白磷酸酶1催化亚基转变为锰离子依赖型酶会削弱其受抑制剂1的调控作用。
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Biochim Biophys Acta. 1980;613(1):95-105. doi: 10.1016/0005-2744(80)90196-5.

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2
Multiforms of megamodulin-dependent protein kinases from baker's yeast.来自面包酵母的巨调节蛋白依赖性蛋白激酶的多种形式。
Mol Cell Biochem. 1984 Sep;64(1):39-44. doi: 10.1007/BF00420926.
3
Regulatory effects of S-100 protein and parvalbumin on protein kinases and phosphoprotein phosphatases from brain and skeletal muscle.
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4
Modulation of protein kinases and phosphoprotein phosphatases by a small acidic protein from bovine brains.牛脑中小酸性蛋白对蛋白激酶和磷蛋白磷酸酶的调节作用。
Experientia. 1985 May 15;41(5):622-3. doi: 10.1007/BF02007688.