多发性硬化症中爱泼斯坦-巴尔病毒转化淋巴细胞的免疫控制

Immunological control of Epstein-Barr virus-transformed lymphocytes in multiple sclerosis.

作者信息

Craig J C, Haire M, Millar J H, Fraser K B, Merrett J D

出版信息

Clin Immunol Immunopathol. 1983 Oct;29(1):86-93. doi: 10.1016/0090-1229(83)90009-0.

Abstract

T-cell control of Epstein-Barr virus (EBV)-infected autologous lymphocytes was examined in 25 multiple sclerosis (MS) patients and in 25 healthy individuals, all seropositive for EBV. By assessing regression of cell transformation, 17 patients and all healthy subjects were scored as "regressors." Eight MS patients proved to be "nonregressors," indicating loss of cytotoxic T-cell control. In this group there was apparently a concurrent fall in the mean titer of antibody to Epstein-Barr nuclear antigen.

摘要

在25例多发性硬化症（MS）患者和25名健康个体中检测了T细胞对爱泼斯坦-巴尔病毒（EBV）感染的自体淋巴细胞的控制情况，所有患者和个体均为EBV血清阳性。通过评估细胞转化的消退情况，17例患者和所有健康受试者被评为“消退者”。8例MS患者被证明是“非消退者”，表明细胞毒性T细胞控制丧失。在这组患者中，爱泼斯坦-巴尔核抗原抗体的平均滴度明显同时下降。