Craig J C, Haire M, Merrett J D
Department of Microbiology and Immunobiology, Queen's University of Belfast.
Clin Immunol Immunopathol. 1988 Sep;48(3):253-60. doi: 10.1016/0090-1229(88)90019-0.
Significantly reduced levels of T-cell-mediated "suppression" of numbers of Epstein-Barr virus (EBV)-activated B lymphocytes which secrete IgG or IgM were found in preparations of mononuclear cells (MNC) from peripheral blood of 28 patients with multiple sclerosis (MS) compared with 28 healthy subjects, all seropositive for EBV. A statistically significant correlation was not found between the suppression of EBV-induced activation of B lymphocytes and either EBV-specific T-cell-mediated cytotoxicity or numbers of T8-positive cells.
与28名健康受试者（均为EBV血清阳性）相比，在28例多发性硬化症（MS）患者外周血单核细胞（MNC）制剂中发现，T细胞介导的对分泌IgG或IgM的EB病毒（EBV）激活的B淋巴细胞数量的“抑制”水平显著降低。在EBV诱导的B淋巴细胞激活的抑制与EBV特异性T细胞介导的细胞毒性或T8阳性细胞数量之间未发现统计学上的显著相关性。
