爱泼斯坦-巴尔病毒对人前B细胞的转化
Epstein-Barr virus transformation of human pre-B cells.
作者信息
Hansson M, Falk K, Ernberg I
出版信息
J Exp Med. 1983 Aug 1;158(2):616-22. doi: 10.1084/jem.158.2.616.
Abstract
In vitro infection of human B lymphocytes with Epstein-Barr virus (EBV) results in establishment of B lymphoblastoid cell lines that reflect normal B cell phenotypes. In this study we have investigated whether immature B cells from fetal bone marrow and liver can serve as targets for EBV. The fetal bone marrow cells were readily transformed by EBV. Among the resulting cell lines, five were surface Ig (sIg)-negative. Three B cell-associated antigens defined by monoclonal antibodies were expressed to the same extent on the fetal cell lines, whether they belonged to the sIg- or sIg+ group. The various differentiation stages that these cell lines may represent are discussed.
摘要
用爱泼斯坦-巴尔病毒（EBV）对人B淋巴细胞进行体外感染，会导致建立起反映正常B细胞表型的B淋巴母细胞系。在本研究中，我们调查了来自胎儿骨髓和肝脏的未成熟B细胞是否可作为EBV的靶细胞。胎儿骨髓细胞很容易被EBV转化。在产生的细胞系中，有五个细胞系表面免疫球蛋白（sIg）呈阴性。由单克隆抗体定义的三种B细胞相关抗原，在胎儿细胞系上的表达程度相同，无论它们属于sIg阴性还是sIg阳性组。讨论了这些细胞系可能代表的不同分化阶段。
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