DeFouw D O, Chinard F P
Microvasc Res. 1983 Jul;26(1):15-26. doi: 10.1016/0026-2862(83)90051-1.
Morphometric comparisons of nonedematous and edematous isolated, perfused dog lungs establish that there are significant differences between the degree of cellular attenuation and vesicle numerical densities in endothelial and type I epithelial cells of the alveolar septa after edema production. In nonedematous isolated lungs the extent of endothelial and epithelial attenuation was greater on the thin sides of the septa. In the edematous lungs, the differential of greater thin-side attenuation was maintained for the endothelium but not for the epithelium where the extent of attenuation in the septal thick segments was increased. Vesicle numerical densities were approximately doubled in the cells on both sides of the septa in the edematous lungs. The endothelial vesicle densities were greater in the septal thin segments than in the septal thick segments in both the nonedematous and the edematous isolated lungs. The epithelial vesicle densities, on the other hand, were similar on the thin and thick sides of the septa in the nonedematous and edematous lung preparations. Although the contribution of vesicles to cellular function in the alveolar septa remains uncertain, further evaluation of vesicular transport should include the possible variability of this function with the varying degrees of cellular attenuation on the two anatomically distinct sides of the septa.
对非水肿性和水肿性离体灌注犬肺进行形态计量学比较发现，肺水肿形成后，肺泡隔内皮细胞和I型上皮细胞的细胞衰减程度和囊泡数量密度存在显著差异。在非水肿性离体肺中，肺泡隔薄侧的内皮细胞和上皮细胞衰减程度更大。在水肿性肺中，内皮细胞仍保持薄侧衰减程度更大的差异，但上皮细胞并非如此，其在肺泡隔厚段的衰减程度增加。水肿性肺中肺泡隔两侧细胞的囊泡数量密度大约增加了一倍。在非水肿性和水肿性离体肺中，肺泡隔薄段的内皮囊泡密度均高于厚段。另一方面，在非水肿性和水肿性肺标本中，肺泡隔薄侧和厚侧的上皮囊泡密度相似。尽管囊泡对肺泡隔细胞功能的作用尚不确定，但对囊泡转运的进一步评估应包括该功能随肺泡隔两个解剖学不同侧细胞衰减程度变化的可能差异。
