合成肽引发和诱导抗脊髓灰质炎病毒中和抗体
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides.
作者信息
Emini E A, Jameson B A, Wimmer E
出版信息
Nature. 1983;304(5928):699-703. doi: 10.1038/304699a0.
DOI:10.1038/304699a0
PMID:6310403
Abstract
Five peptides containing amino acid sequences from the type 1 poliovirus structural protein VP1 have been synthesized. Each of the peptides was found capable of priming the immune system of rabbits for a long-lasting, virus-neutralizing IgG antibody response following a single inoculation of intact virus. One peptide directly induced the production of neutralizing antibody.
摘要
已合成了五种含有1型脊髓灰质炎病毒结构蛋白VP1氨基酸序列的肽。发现每种肽在单次接种完整病毒后，都能够使兔的免疫系统产生持久的病毒中和IgG抗体反应。一种肽直接诱导中和抗体的产生。
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