脊髓灰质炎病毒中和抗体反应的肽引发作用。
Peptide priming of a poliovirus neutralizing antibody response.
作者信息
Wimmer E, Emini E A, Jameson B A
出版信息
Rev Infect Dis. 1984 May-Jun;6 Suppl 2:S505-9. doi: 10.1093/clinids/6.supplement_2.s505.
Two peptides representing neutralizing epitope-containing regions of the capsid protein VP1 of type 1 poliovirus were chemically synthesized. Both peptides were found capable of priming rabbits for a significant, long-lasting, anti-virus neutralizing IgG response following a single inoculation of intact virion. In addition, a third synthetic peptide, an extended version of one of the two priming peptides, was capable of eliciting a neutralizing antibody response following inoculation of the carrier-linked peptide alone.
化学合成了代表1型脊髓灰质炎病毒衣壳蛋白VP1含中和表位区域的两种肽。发现这两种肽在单次接种完整病毒体后，都能够使兔子产生显著、持久的抗病毒中和IgG反应。此外，第三种合成肽，即两种引发肽之一的延伸版本，在单独接种载体连接肽后能够引发中和抗体反应。
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