Wood P L, Pasternak G W
Neurosci Lett. 1983 Jun 30;37(3):291-3. doi: 10.1016/0304-3940(83)90446-9.
The irreversible mu 1 opiate antagonist, naloxonazine, totally blocked the analgesic actions (tail-flick assay) of morphine (8 mg/kg) in the rat. However, this treatment was without effect on the morphine-dependent (4 mg/kg) increases in striatal dopamine metabolism. These data support our previous studies which have suggested mu 2 and delta opioid receptor regulation of the rat nigrostriatal pathway.
