Wood P L, McQuade P, Richard J W, Thakur M
Life Sci. 1983;33 Suppl 1:759-62. doi: 10.1016/0024-3205(83)90613-6.
Agonist/antagonist (Ag/Ant) analgesics possess bell-shaped dose-response curves with regard to nigrostriatal dopamine (DA) metabolism in the rat. Using local drug injections as well as parenteral drug, after acute hemisection, we have determined that this phenomenon is not the result of autoinhibition. Our data clearly indicate that the receptor population antagonizing the agonist actions of Ag/Ant is not localized within the striatum or substantia nigra. These results therefore present evidence for receptor dualism with Ag/Ant analgesics.
激动剂/拮抗剂（Ag/Ant）镇痛药在大鼠黑质纹状体多巴胺（DA）代谢方面呈现钟形剂量-反应曲线。通过局部药物注射以及肠胃外给药，在急性半切术后，我们已确定这种现象并非自身抑制的结果。我们的数据清楚地表明，拮抗Ag/Ant激动剂作用的受体群体并不定位于纹状体或黑质内。因此，这些结果为Ag/Ant镇痛药的受体二元论提供了证据。
