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小鼠转座子样重复DNA序列的早期差异组织表达

Early differential tissue expression of transposon-like repetitive DNA sequences of the mouse.

作者信息

Brûlet P, Kaghad M, Xu Y S, Croissant O, Jacob F

出版信息

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5641-5. doi: 10.1073/pnas.80.18.5641.

DOI:10.1073/pnas.80.18.5641
PMID:6310586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC384314/
Abstract

Another family of long moderately repetitive and dispersed sequences has been identified in the mouse genome. These sequences have a transposon-like structure. A 6-kilobase RNA transcript is detected in undifferentiated embryonal carcinoma cell lines but not in any of the differentiated cell types tested. By R-loop formation, the RNA is colinear with a DNA fragment from a randomly selected genomic clone.

摘要

在小鼠基因组中鉴定出了另一类长的中度重复且分散的序列。这些序列具有类似转座子的结构。在未分化的胚胎癌细胞系中检测到一种6千碱基的RNA转录本，但在任何测试的分化细胞类型中均未检测到。通过R环形成，该RNA与来自随机选择的基因组克隆的DNA片段共线。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/8bb9bdf584be/pnas00644-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/04e06c5134a0/pnas00644-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/a6de65a961a1/pnas00644-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/a056398f34d5/pnas00644-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/b955da01f894/pnas00644-0196-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/8bb9bdf584be/pnas00644-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/04e06c5134a0/pnas00644-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/a6de65a961a1/pnas00644-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/a056398f34d5/pnas00644-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/b955da01f894/pnas00644-0196-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ded6/384314/8bb9bdf584be/pnas00644-0197-a.jpg

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