精神药理学研究中的血小板
Blood platelets in psychopharmacological research.
作者信息
Rotman A
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):135-51. doi: 10.1016/0278-5846(83)90101-x.
PMID:6310688
Abstract
Blood platelets are a very good model for nerve endings, for study of serotonin uptake and imipramine binding. The efficiency of various drugs, mainly antidepressants, can be evaluated using blood platelets instead of synaptosomes. A few neuronal active compounds are effective in inducing platelet secretion and shape change reaction. Platelet MAO and c-AMP levels are not yet established as useful in psychopharmacological studies.
摘要
血小板是研究神经末梢、5-羟色胺摄取和丙咪嗪结合的良好模型。可以使用血小板而非突触体来评估各种药物（主要是抗抑郁药）的疗效。一些神经元活性化合物能有效诱导血小板分泌和形状改变反应。血小板单胺氧化酶和环磷酸腺苷水平在精神药理学研究中的作用尚未明确。
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